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Search Results for " renal failure "

31

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T1615	Irbesartan 厄贝沙坦,SR-47436,BMS-186295	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。
TQ0157	EIPA L593754,MH 12-43	Sodium Channel; TRP/TRPV Channel	Membrane transporter/Ion channel
	EIPA (L593754) 是一种有效的TRPP3 channel 抑制剂，IC50为 10.5 μM。EIPA 对Na+/H+交换 (NHE) 和巨噬细胞也有抑制作用。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T1182	Levocarnitine propionate hydrochloride Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,丙酰左旋肉碱盐酸盐,ST-261,丙酰肉碱盐酸盐	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocarnitine propionate hydrochloride (ST-261) 可用于肾功能恶化，充血性心脏衰竭，间歇性跛行等疾病的研究。
T22882	JP1302	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	JP1302 是一种具有选择性的 α2C 肾上腺受体拮抗剂，其对人类 α2C 受体的 Kb 值为 16 nM，Ki 为 28 nM。JP1302 具有抗抑郁活性，可破坏 FACT 复合物并降解组蛋白H1，可用于研究神经精神障碍、急性肾功能衰竭和肾损伤。
TQ0200	Paricalcitol
	Paricalcitol 是一种 vitamin D receptor 激活剂，是一种 vitamin D 类似物，用于研究继发性甲状旁腺功能亢进，该疾病与慢性肾功能衰竭有关。
T16782	Rolofylline KW-3902,MK-7418,KF-15372	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Rolofylline (KW-3902) 是一种具有选择性腺苷 A1 受体拮抗剂，可用于研究急性充血性心力衰竭和肾功能障碍，可用与研究神经退行性疾病。
T61383	Diaziquone NSC 182986
	Diaziquone (NSC-182986)是一种水溶性的合成的氮杂环苯醌，可增强对血脑屏障的渗透，具有抗肿瘤活性，可用于治疗极性肾功能衰竭。
T17284	Zardaverine BY 290,B 84290	PDE	Metabolism
	Zardaverine (BY 290) 是一种可口服且具有选择性和有效性的 PDE3/4 抑制剂，具有支气管扩张活性和抗肝癌活性。Zardaverine 在血小板中的作用是通过PDE III同工酶介导，可用于研究急性肾衰竭呵呵慢性气流阻塞。
T28222	5-Hydroxy-1-methylhydantoin HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor	GPCR/G Protein
	5-Hydroxy-1-methylhydantoin (HD-003) 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物，是一种羟基自由基清除剂，此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。它是一种新型抗氧化药物，可完全抑制 B2-激肽受体(B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应，并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明，它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。
T31594	EA-230 EA 230,NMPF-46,NMPF46,NMPF 46
	Ea-230 is an immunomodulator that may be used in the treatment of renal failure.
T33856	PA 21 PA21
	PA 21 is an iron-based noncalcium phosphate binder that prevents vascular calcification in chronic renal failure rats.
T33600	Naxifylline CVT 124,CVT-124,CVT124,BG9719
	Naxifylline is an A1 adenosine receptor antagonist that promotes urine volume to prevent the decline in renal function observed during diuretic therapy for the treatment of edema associated with congestive heart failure.
T70480	FPL-65447 hydrochloride
	FPL-65447 hydrochloride is a selective D1 receptor agonist that has potential for the acute treatment of renal and cardiac failure and of sepsis and septic shock.
T80891	Urodilatin
	Urodilatin为ANF-(99-126)的同类物，属于利尿钠调节肽。该化合物主要应用于急性肾功能衰竭、充血性心力衰竭、支气管哮喘等疾病的研究领域。
T12363	Paricalcitol-D6	Others	Others
	Paricalcitol-D6 is the deuterated form of Paricalcitol, which is used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
T1400L	Demeclocycline Ledermycin,Bioterciclin,Deteclo,Declostatin,Deganol	Antibacterial	Microbiology/Virology
	Demeclocycline (Declostatin) 是一种四环素类抗生素，产自金霉素链霉菌（Streptomyces aureofaciens）菌株。Demeclocycline 具有抗菌活性，能抑制血管加压素对肾小管的作用，从而导致利尿。Demeclocycline 可用诱导尿崩症和急性肾衰竭。
T76125	Creatininase CAH,Creatinine amidohydrolase	Endogenous Metabolite	Metabolism
	Creatininase (CAH) 是一种从 Pseudomonas putida 中发现的同六聚体酶，可用于研究肌酐检测的生物传感器和慢性肾功能衰竭。
T75272	Paricalcitol-d
	Paricalcitol-d6，是一种Paricalcitol的氘代物，主要用于治疗与慢性肾衰竭相关的继发性甲状旁腺机能亢进。
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
T82941	Atriopeptin III (rat) ANP 127-150 (rat)
	Atriopeptin III (ANP 127-150) (rat)是包含24个氨基酸的心房肽，作用为有效的血管舒张剂及利尿剂。在输尿管梗阻大鼠模型中，Atriopeptin III (rat)能够改善肾功能并降低血压，同时适用于慢性肾功能衰竭研究。
T39063	Azilsartan mepixetil
	Azilsartan mepixetil is a potent angiotensin II receptor antagonist with enhanced efficacy and prolonged duration of action. It exhibits more prominent and sustained effects in lowering blood pressure and heart rate, while maintaining a high level of safety. Furthermore, Azilsartan mepixetil demonstrates optimal protective efficacy for cardiovascular and renal functions. Hence, it holds promise for the research and treatment of hypertension, chronic heart failure, and diabetic nephropathy.
T61983	Trichlormethiazide sodium
	Trichlormethiazide sodium 是口服有效的噻嗪类利尿剂，显示降压活性。在急性肾功能衰竭大鼠中，Trichlormethiazide sodium 可增加尿量、Na 和 K 排泄，并有改善肌酐清除率 (CCRE)。
T33851	Ozolinone W 3282,W3282,W-3282
	Ozolinone is an active metabolite of etozoline which acts as a loop diuretic --- a diuretic that acts at the ascending limb of the loop of Henle in the kidney. Loop diuretics are primarily used in medicine to treat hypertension and edema often due to cong
T62909	SGC agonist 2
	SGC agonist 2 是一种有效的可溶性鸟苷酸环化酶 (SGC) 激动剂。其中可溶性鸟苷酸环化酶是 NO-sGC-cGMP 信号通路中的关键信号转导酶。SGC agonist 2 具有潜力进行心血管疾病 (心力衰竭、心绞痛、肺动脉高压、心肌梗塞) 和纤维化疾病 (肾纤维化、系统性硬化症) 的研究。
T76762	Tabalumab
	Tabalumab (LY2127399) 是一种人源化的抗BAFF(B 细胞激活因子) 单克隆抗体 (IgG4 型)，对膜结合和可溶性BAFF 具有中和活性。Tabalumab 可用于自身免疫性疾病，如类风湿性关节炎、肾衰竭和系统性红斑狼疮的研究。
T62134	A1/A3 AR antagonist 1
	A1/A3 AR antagonist 1 (compound 10) 是一种有效的、双重腺苷酸 1 (A1)和腺苷酸 3 (A3)受体拮抗剂，能够作用于人 A1 (Ki: 37.6 nM)、人 A3 (Ki: 25.4 nM) 和大鼠 A1 (Ki: 1.47 nM)。A1/A3 AR antagonist 1 能够用于研究肾衰竭、炎症性肺部疾病和阿尔茨海默症。
T70990	ADMA-d6
	NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da...
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...

化合物

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Cat.No: T7714

Target: Tyrosinase

Cat.No: T1615

Synonym: 厄贝沙坦,SR-47436,BMS-186295

Target: Apoptosis, RAAS

Cat.No: TQ0157

Synonym: L593754,MH 12-43

Target: Sodium Channel, TRP/TRPV Channel

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

Levocarnitine propionate hydrochloride

Cat.No: T1182

Synonym: Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,丙酰左旋肉碱盐酸盐,ST-261,丙酰肉碱盐酸盐

Target: Histamine Receptor

Cat.No: T22882

Target: Adrenergic Receptor

Cat.No: TQ0200

Cat.No: T16782

Synonym: KW-3902,MK-7418,KF-15372

Target: Adenosine Receptor

Cat.No: T61383

Synonym: NSC 182986

Cat.No: T17284

Synonym: BY 290,B 84290

Target: PDE

5-Hydroxy-1-methylhydantoin

Cat.No: T28222

Synonym: HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419

Target: Bradykinin Receptor

Cat.No: T31594

Synonym: EA 230,NMPF-46,NMPF46,NMPF 46

Cat.No: T33856

Synonym: PA21

Cat.No: T33600

Synonym: CVT 124,CVT-124,CVT124,BG9719

FPL-65447 hydrochloride

Cat.No: T70480

Cat.No: T80891

Paricalcitol-D6

Cat.No: T12363

Target: Others

Cat.No: T1400L

Synonym: Ledermycin,Bioterciclin,Deteclo,Declostatin,Deganol

Target: Antibacterial

Cat.No: T76125

Synonym: CAH,Creatinine amidohydrolase

Target: Endogenous Metabolite

Cat.No: T75272

Cat.No: T71065

Atriopeptin III (rat)

Cat.No: T82941

Synonym: ANP 127-150 (rat)

Azilsartan mepixetil

Cat.No: T39063

Trichlormethiazide sodium

Cat.No: T61983

Cat.No: T33851

Synonym: W 3282,W3282,W-3282

Cat.No: T62909

Cat.No: T76762

A1/A3 AR antagonist 1

Cat.No: T62134

Cat.No: T70990

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

Cat. No.	Product Name	Target	Signaling Pathways
T3999	D(+)-Galactosamine hydrochloride D-半乳糖胺盐酸盐,D-氨基半乳糖盐酸盐,D-Galactosamine HCl	Others	Others
	D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) 是一种被证实的实验毒素，它能够产生自由基及UTP 核苷酸的消耗导致肝损伤，中毒剂量会造成肾功能不全，而肾功能衰竭通常和终末期肝损伤有关。脂多糖/D-Galactosamine 诱导的急性肝损伤是一种已知的暴发性肝衰竭动物模型。
T8150	Nudifloramide 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺	PARP; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) 是烟酰胺-腺嘌呤二核苷酸(NAD) 降解的一种最终产物，可显著抑制PARP-1活性。
T4238	Glycocyamine 乙酸胍,2-Guanidinoacetic acid,Guanidoacetic acid	Others; Endogenous Metabolite	Metabolism; Others
	Glycocyamine (2-Guanidinoacetic acid) 是一种肌酸的前体，能够为鸟类的体内平衡提供能量，也能够成为食用精氨酸的替代物。
T20793	Magnesium Lithospermate B 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B	Others	Others
	Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物，从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究，并且可以防止葡萄糖引起的细胞内氧化损伤。
T0414	D-Mannitol Mannite,Mannitol,D-甘露糖醇,Osmitrol	Apoptosis; Dehydrogenase; Endogenous Metabolite	Apoptosis; Metabolism
	D-Mannitol (Mannitol) 是与山梨醇相关的利尿剂和肾脏诊断辅助剂，具有较弱的肾脏血管扩张活性。
T4904	1-Methylguanidine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	1-Methylguanidine hydrochloride 是内源性代谢产物的一种。
TN1912	Marinobufogenin 南美蟾毒精,Marinobufagenin	ATPase; EGFR	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.

天然产物

D(+)-Galactosamine hydrochloride

Cat.No: T3999

Synonym: D-半乳糖胺盐酸盐,D-氨基半乳糖盐酸盐,D-Galactosamine HCl

Target: Others

Cat.No: T8150

Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺

Target: PARP, Endogenous Metabolite

Cat.No: T4238

Synonym: 乙酸胍,2-Guanidinoacetic acid,Guanidoacetic acid

Target: Others, Endogenous Metabolite

Magnesium Lithospermate B

Cat.No: T20793

Synonym: 丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B

Target: Others

Cat.No: T0414

Synonym: Mannite,Mannitol,D-甘露糖醇,Osmitrol

Target: Apoptosis, Dehydrogenase, Endogenous Metabolite

1-Methylguanidine hydrochloride

Cat.No: T4904

Target: Others, Endogenous Metabolite

Marinobufogenin

Cat.No: TN1912

Synonym: 南美蟾毒精,Marinobufagenin

Target: ATPase, EGFR

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